Some selected comments about the human genome from Nature, February 15, 2001:

1.  It is the largest genome to be extensively sequenced so far, being 25 times as large
     as any previously sequenced genome and eight times as large as the sum of all such

2.  It is the first vertebrate genome to be extensively sequenced.

3.  There appear to be about 30,000–40,000 protein-coding genes in the human
     genome—only about twice as many as in worm or fly. However, the genes are
     more complex, with more alternative splicing generating a larger number of
     protein products.

4.  Hundreds of human genes appear likely to have resulted from horizontal transfer
     from bacteria at some point in the vertebrate lineage. Dozens of genes appear to
     have been derived from transposable elements.

5.  Although about half of the human genome derives from transposable elements,
     there has been a marked decline in the overall activity of such elements in the
     hominid lineage. DNA transposons appear to have become completely inactive
     and long-terminal repeat (LTR) retroposons may also have done so.

6.  Analysis of the organization of Alu elements explains the longstanding mystery of
     their surprising genomic distribution, and suggests that there may be strong
     selection in favour of preferential retention of Alu elements (a sequence found
     in the tissue plasminogen activator gene in chromosome 8) in GC-rich regions
     and that these 'selfish' elements may benefit their human hosts.

7.  The mutation rate is about twice as high in male as in female meiosis, showing that
     most mutation occurs in males.

8.  More than 1.4 million single nucleotide polymorphisms (SNPs) in the human
     genome have been identified. This collection should allow the initiation of
     genome-wide linkage disequilibrium mapping of the genes in the human population.