The Chemistry of Cisplatin
What type of geometry do the two isomers of PtCl2(NH3)2 have?
Cis isomer .......................................Trans isomer
Hydrolysis of cisplatin
PtCl2(NH3)2 + H2O = PtCl(NH3)2H2O+ + Cl-
Binding occurs in cells where chloride concentration is low.
The cis isomer, after hydrolysis of the Cl groups, binds to two side-by-side guanines on DNA.
The base guanine to the left and the base on the DNA backbone to the right.
The cisplatin bound to DNA